PO-03-095 SEX-RELATED DIFFERENCES IN ATRIAL SUBSTRATE IN PATIENTS UNDERGOING PULMONARY VEIN ISOLATION; A PROSPECTIVE, MULTICENTER STUDY

Sex-related differences have been reported among patients undergoing pulmonary vein isolation (PVI). Atrial substrate plays a major role in the outcomes after ablation but sex-related atrial never described detail. We sought to analyze remodeling (spontaneous low-voltage zones (LVZ)) and their clinical relevance PVI. conducted prospective multicenter study, including consecutive first PVI-only AF ablation. LVZs were analyzed on high-density electroanatomical maps collected with multipolar catheter, prior 262 (61±11 years, 31% females, 50% persistent AF) followed for 28 months. In women, larger (10% vs. 4% of LA surface (p < 0.001)) more women had high-burden (>15%) (24% 8% 0.001)). spite having advanced remodeling, recurrence-free survival was similar between men (Log-Rank p=0.2). The presence >5% LVZ significantly associated recurrence (HR:3.0, p<0.001) not (HR:1.9, p=0.07). only >15% (HR: 2.7, p=0.02). Women widespread all regions. Despite extensive efficacy is become prognostic at high burden (>15%). seem different women.